Once this nanomedicine is injected into the blood and goes through the spleen and liver, the immune system is re-taught that healthy myelin is not an invading outside threat and should be left alone and the autoimmune cells becomes “tolerized”. Drs. Miller and Popko are also combining the tolerance protocol with co-administration of drugs that stimulate myelin repair and have found that combined treatment with both strategies leads to a remarkable ability to reverse symptoms of MS in a mouse model of the disease. Promising agents which are being tested for their ability to promote myelin repair include the FDA approved drugs digoxin (used in heart therapy ) and miconazole (an anti-fungal drug) as well as a new approach being tested in collaboration with Clene Nanomedicine which uses the administration of gold nanocrystals. The money we raised last year allowed our researchers to complete crucial work so they could be compete for more grant money from The National Institutes of Health – a new NIH grant was awarded jointly to them in July 2017.
This research has the potential to revolutionize autoimmune and allergic disease treatment since you can substitute the myelin proteins for other proteins depending on the disease being targeted. Therefore you can tolerize the immune system in response to all autoimmune diseases including type 1 diabetes, rheumatoid arthritis, Celiac disease and lupus. Additionally, you can control severe allergies, including to peanut and cat dander and even eliminate organ transplant rejections. So, our great philanthropic endeavors will benefit many people we know and love that fit into these expanded categories. Dr. Miller’s company, Cour Pharmaceutical Development Company in collaboration with Takeda Pharmaceuticals began an FDA-approved phase 1 clinical trial in celiac patients who are being treated with nanoparticles containing gliadin (the major protein component of gluten) to re-establish tolerance and hopefully stop this widespread disease.
Join us and be part of our team; walk and donate
If you can’t make the trip join our group by donating online through Northwestern Univ..
Or by writing a check:
Memo: CATalyzer project
c/o Bob Gregory
10 Londonderry Lane
Lincolnshire, IL 60069
The Sunday Walk has morphed into a fun weekend. Our out of town team members come in early. These include our perennial All-Star, Mike Lazarus, from Connecticut, a number of my classmates from the class of 1974 Emerson NJ high schhigh schoolhigh school, my sister Cathy and brother-in-law Tim from Charlotte and my daughter, Christine, parachuting in from Bogotá.